Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities
| Autor: | Simone C. B. Gnoatto, Jarbas R. de Oliveira, Grace Gosmann, Vanusa Manfredini, Carmen Regla Vargas, Lucimara N. Comunello, Robson H. Amaral, Gabriela Lucas da Silva, Cristiane B. de Oliveira, Adroaldo Lunardelli, Melissa G. S. Pires |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Molecules, Vol 17, Iss 1, Pp 1113-1123 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1420-3049 83848746 |
| DOI: | 10.3390/molecules17011113 |
| Popis: | Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds. |
| Databáze: | Directory of Open Access Journals |
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