| Autor: |
Adilson Santos Andrade-Sousa, Paulo Rogério Pereira, BreAnne MacKenzie, Manoel Carneiro Oliveira-Junior, Erasmo Assumpção-Neto, Maysa Alves Rodrigues Brandão-Rangel, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Pereira Velosa, Walcy Rosolia Teodoro, Ana Paula Ligeiro de Oliveira, Marisa Dolhnikoff, Oliver Eickelberg, Rodolfo Paula Vieira |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 11, Iss 9, p e0163420 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0163420 |
| Popis: |
INTRODUCTION:The aim of this study was to investigate the effect of aerobic exercise (AE) in reducing bleomycin-induced fibrosis in mice of a Th2-dominant immune background (BALB/c). METHODS:BALB/c mice were distributed into: sedentary, control (CON), Exercise-only (EX), sedentary, bleomycin-treated (BLEO) and bleomycin-treated+exercised (BLEO+EX); (n = 8/group). Following treadmill adaptation, 15 days following a single, oro-tracheal administration of bleomycin (1.5U/kg), AE was performed 5 days/week, 60min/day for 4 weeks at moderate intensity (60% of maximum velocity reached during a physical test) and assessed for pulmonary inflammation and remodeling, and cytokine levels in bronchoalveolar lavage (BAL). RESULTS:At 45 days post injury, compared to BLEO, BLEO+EX demonstrated reduced collagen deposition in the airways (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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