Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants

Autor: Yu Wang, Fabiana Subrizi, Eve M. Carter, Tom D. Sheppard, John M. Ward, Helen C. Hailes
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33122-1
Popis: Pharmaceuticals derived from benzylisoquinoline alkaloids find application in modern medicine. Here, the authors report the design of a parallel enzymatic cascade to generate halogenated benzylisoquinoline alkaloids, that included engineering of tyrosinase mutants to enhance substrate capabilities.
Databáze: Directory of Open Access Journals