The Association of Plasma Folate, Vitamin B12 and Homocysteine Levels on Hypermethylation Status of RARβ2 Gene in Primary Breast Carcinoma

Autor:	S Pirouzpanah, FA Taleban, AR Abadi, M Atri, P Mehdipour
Jazyk:	perština
Rok vydání:	2009
Předmět:	Breast cancer ، Hypermethylation ، RARβ2 ، Folate ، Vitamin B12 ، Total homocysteine Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	مجله اپیدمیولوژی ایران, Vol 5, Iss 2, Pp 19-27 (2009)
Druh dokumentu:	article
ISSN:	1735-7489 2228-7507
Popis:	Background & Objectives: The repression of retinoic acid receptor-β2 (RARβ2) expression is a concerning aspect of breast cancer, which is often induced by hypermethylation at promoter of the gene. We aimed to explore the correlation of plasma folate, vitamin B12 and total homocysteine (tHcy) levels with hypermethylation status of RARβ2 gene among Iranian breast cancer patients. Methods: The hypermethylation status was investigated in 137 specimens tissues from primary breast cancer patients aged 28-85 years thorough methylation-specific PCR. Results: Hypermethylation at RARβ2 gene was observed in 36.5 %. The hypermthylated RARβ2 associated with younger age at diagnosis and negative family history of breast cancer. The plasma level of folate was found lower in cases aged ≥48 years with hypermethylated RARβ2 gene (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b0b892deb4a74d729a58fb131b63ce76 Zobrazit plný text záznamu View record in DOAJ