Interpreting the pervasive observation of U-shaped Site Frequency Spectra.
Autor: | Fabian Freund, Elise Kerdoncuff, Sebastian Matuszewski, Marguerite Lapierre, Marcel Hildebrandt, Jeffrey D Jensen, Luca Ferretti, Amaury Lambert, Timothy B Sackton, Guillaume Achaz |
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Jazyk: | angličtina |
Rok vydání: | 2023 |
Předmět: | |
Zdroj: | PLoS Genetics, Vol 19, Iss 3, p e1010677 (2023) |
Druh dokumentu: | article |
ISSN: | 1553-7390 1553-7404 |
DOI: | 10.1371/journal.pgen.1010677 |
Popis: | The standard neutral model of molecular evolution has traditionally been used as the null model for population genomics. We gathered a collection of 45 genome-wide site frequency spectra from a diverse set of species, most of which display an excess of low and high frequency variants compared to the expectation of the standard neutral model, resulting in U-shaped spectra. We show that multiple merger coalescent models often provide a better fit to these observations than the standard Kingman coalescent. Hence, in many circumstances these under-utilized models may serve as the more appropriate reference for genomic analyses. We further discuss the underlying evolutionary processes that may result in the widespread U-shape of frequency spectra. |
Databáze: | Directory of Open Access Journals |
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