| Autor: |
Guilford Parry, Blair Vanessa, More Helen, Humar Bostjan |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Hereditary Cancer in Clinical Practice, Vol 5, Iss 4, Pp 183-194 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1897-4287 |
| DOI: |
10.1186/1897-4287-5-4-183 |
| Popis: |
Abstract Hereditary diffuse gastric cancer (HDGC) is the only known predisposition syndrome dominated by carcinoma of the stomach and with a recognised genetic cause. Germline mutations in the E-cadherin gene (CDH1) co-segregate with the disease in about half of the families with multiple diffuse gastric cancer. In these families, identification of the CDH1 mutation allows for clinical measures to be taken. Importantly, clinical intervention is likely to be therapeutic and associated with tolerable morbidity. This review is thus aimed at providing a current overview of the clinical management and the underlying biology of HDGC. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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