| Autor: |
Henriqueta Dias Cardoso, Priscila Pereira Passos, Cláudia Jacques Lagranha, Anete C Ferraz, Eraldo Fonseca Santos Junior, Rafael Salomé Oliveira, Pablo Emanuel Lisboa de Oliveira, Rita de Cássia Farias Santos, David Filipe de Santana, Juliana Maria Carrazone Borba, Ana Paula eRocha-de-Melo, Rubem Carlos Araújo Guedes, Daniela Maria do Amaral Ferraz Navarro, Geanne Karla Novais Santos, Roseane eBorner, Cristovam Wanderley Picanço Diniz, Eduardo Isidoro Beltrão, Janilson Félix da Silva, Marcelo Cairrão Araújo Rodrigues, Belmira Lara Da Silveira Andrade- Da- Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Frontiers in Human Neuroscience, Vol 6 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1662-5161 |
| DOI: |
10.3389/fnhum.2012.00249 |
| Popis: |
Oxidative stress (OS) has been implicated in the etiology of certain neurodegenerative disorders. Some of these disorders have been associated with unbalanced levels of essential fatty acids (EFA). The response of certain brain regions to OS, however, is not uniform and a selective vulnerability or resilience can occur. In our previous study on rat brains, we observed that a two-generation EFA dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (SN) rostro-dorso-medial. To understand whether OS contributes to this effect, we assessed the status of lipid peroxidation and anti-oxidant markers in both SN and corpus striatum (CS) of rats submitted to this dietary treatment for one (F1) or two (F2) generations. Wistar rats were raised from conception on control or experimental diets containing adequate or reduced levels of linoleic and α-linolenic fatty acids, respectively. Lipid peroxidation (LP) was measured using the thiobarbituric acid reaction method (TBARS) and the total superoxide dismutase (t-SOD) and catalase (CAT) enzymatic activities were assessed. The experimental diet significantly reduced the docosahexaenoic acid levels of SN phospholipids in the F1 (~28%) and F2 (~50%) groups. In F1 adult animals of the experimental group there was no LP in both SN and CS. Consistently, there was a significant increase in the t-SOD activity (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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