Case report: Germline BRCA 2 mutation in primary peritoneal carcinoma: a rare malignancy

Autor: Yan-Ying Huang, Yue Zhang, Wen-Jun Xie, Zhao-Dong Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Oncology, Vol 14 (2024)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2024.1428918
Popis: BackgroundPrimary peritoneal carcinoma (PPC) is a rare malignancy. Clinically, its histological morphology resembles that of epithelial ovarian tumors (EOC), often leading to misdiagnosis. Diagnosis and treatment of PPC are time-sensitive because of the rapidly progressive nature of the disease.Case reportHerein, we report the case of a 54-year-old woman who was initially diagnosed with ovarian cancer; however, extensive workup showed evidence of Müllerian PPC origin. Furthermore, the patient harbored a targetable BRCA mutation.ConclusionThe patient was treated with the BRCA-targeting agents and had a good prognosis after surgery.
Databáze: Directory of Open Access Journals