Radiopharmaceutical Labelling for Lung Ventilation/Perfusion PET/CT Imaging: A Review of Production and Optimization Processes for Clinical Use

Autor:	Frédérique Blanc-Béguin, Simon Hennebicq, Philippe Robin, Raphaël Tripier, Pierre-Yves Salaün, Pierre-Yves Le Roux
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	V/Q PET/CT [68Ga]Ga-MAA 68Ga-labelled carbon nanoparticles Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 15, Iss 5, p 518 (2022)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph15050518
Popis:	Lung ventilation/perfusion (V/Q) positron emission tomography-computed tomography (PET/CT) is a promising imaging modality for regional lung function assessment. The same carrier molecules as a conventional V/Q scan (i.e., carbon nanoparticles for ventilation and macro aggregated albumin particles for perfusion) are used, but they are labeled with gallium-68 (68Ga) instead of technetium-99m (99mTc). For both radiopharmaceuticals, various production processes have been proposed. This article discusses the challenges associated with the transition from 99mTc- to 68Ga-labelled radiopharmaceuticals. The various production and optimization processes for both radiopharmaceuticals are reviewed and discussed for optimal clinical use.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b0871065f0e447a5b838c9eb3dda0793 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.