| Autor: |
George Madaha, Fortunatus Jacob, Fulgence Ntangere Mpenda |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
International Journal of Secondary Metabolite, Vol 11, Iss 4, Pp 675-686 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2148-6905 |
| DOI: |
10.21448/ijsm.1445869 |
| Popis: |
Bleeding from a wound as a result of physical injury is a life-threatening condition. In pursuing new drug structures, the effect of crude fungal extracts fungal isolated from Jatropha multifida on wound healing and coagulation of mouse whole blood was investigated. Jatropha multifida leaves were sterilized, cut into small segments, and then incubated in Potato Dextrose Agar for seven days. Four isolates were purified and their morphologies were characterized. Identification of isolates was confirmed by a molecular protocol. Two crude extracts from Phlebiopsis gigantea (OK021602) and Phyllosticta sp (OK021603), which exhibited higher phytochemicals composition, were selected and evaluated using wound excision and coagulation of mouse whole blood, by administering 30 µg/mL, 50 µg/mL and 70 µg/mL crude extracts respectively. The percentage of wound healing in mice was higher (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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