| Autor: |
Jennifer K Y Ko, Jinghua Shi, Raymond H W Li, William S B Yeung, Ernest H Y Ng |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Endocrine Connections, Vol 11, Iss 2, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2049-3614 |
| DOI: |
10.1530/EC-21-0444 |
| Popis: |
Objective: Vitamin D receptors are present in the female reproductive tract. Studies on the association between serum vitamin D level and pregnancy rate of in vitro fertilization (IVF) showed inconsistent results and focused on a single fresh or frozen embryo transfer cycle. The objective of our study was to evaluate if serum vitamin D level before ovarian stimulation was associated with the cumulative live bir th rate (CLBR) of the first IVF cycle. Design: Retrospective cohort study. Methods: Women who underwent the first IVF cycle from 2012 to 2016 at a university-affiliated reproductive medicine center were included. Archived s erum samples taken before ovarian stimulation were analyzed for 25(OH)D levels using liquid chromatography-mass spectrometry. Results: In total, 1113 had pregnancy outcome from the completed IVF cycle. The median age (25th–75th percentile) of the women was 36 (34–38) years an d serum 25(OH)D level was 53.4 (41.9–66.6) nmol/L. The prevalence of vitamin D deficie ncy (less than 50 nmol/L) was 42.2%. The CLBR in the vitamin D-deficient group was signific antly lower compared to the non-deficient group (43.9%, 208/474 vs 50.9%, 325/639, P = 0.021, unadjusted), and after controlling for women’s age, BMI, antral follicle count, type and duration of infertility. There were no differences in the clinical/ongoing p regnancy rate, live birth rate and miscarriage rate in the fresh cycle between the vitamin D d eficient and non-deficient groups. Conclusions: Vitamin D deficiency was prevalent in infertile women in subtro pical Hong Kong. The CLBR of the first IVF cycle in the vitamin D-deficient group was significantly lower compared to the non-deficient group. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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