RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Autor: Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11246-1
Popis: Replication fork degradation can result in genome instability. Here authors reveal a role for Rif1 protein in protecting stalled replication forks from undergoing extensive, DNA2-dependent, degradation.
Databáze: Directory of Open Access Journals