| Autor: |
Omar Chehab, MD, MSc, Said El Zein, MD, Amjad Kanj, MD, MPH, Adel Moghrabi, MBBS, Joseph Sebastian, MD, Adnan Halboni, MD, Samer Alkassis, MD, Nivine El-Hor, MD, Alexandros Briasoulis, MD, PhD, Randy Lieberman, MD, PhD, Luis Afonso, MD, Pranatharthi Chandrasekar, MD, Aiden Abidov, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 5, Pp 891-897 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2542-4548 |
| DOI: |
10.1016/j.mayocpiqo.2021.08.005 |
| Popis: |
To evaluate the association of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initial viral load (iVL) and the incidence of myocardial injury (MCI) in hospitalized patients with SARS-CoV-2 infection, we conducted a retrospective longitudinal study of hospitalized patients who had a nasopharyngeal swab sample on admission that returned a positive result for SARS-CoV-2 by polymerase chain reaction between April 4 and June 5, 2020. The cycle threshold (Ct) value was used as a surrogate for the iVL level, with a Ct level of 36 or less for elevated iVL and greater than 36 for low iVL. Myocardial injury was defined as an elevated high-sensitivity cardiac troponin I level that was higher than the 99th percentile upper reference limit. A total of 270 patients were included. Of these, 171 (63.3%) had an elevated iVL and 88 (32.6%) had MCI. There was no significant difference in the incidence of MCI in patients with low iVL compared to those with elevated iVL (28 of 99 [28.3%] vs 60 of 171 [35.1%]; P=.25). In a multivariable model, MCI (odds ratio, 3.86; 95% CI, 1.80 to 8.34; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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