The impact of interaction between verteporfin and yes-associated protein 1/transcriptional coactivator with PDZ-binding motif-TEA domain pathway on the progression of isocitrate dehydrogenase wild-type glioblastoma
| Autor: | Mahmoud Osama MD, Muhammed Amir Essibayi MD, Mona Osama B Pharm, Ismail A. Ibrahim, Mostafa Nasr Mostafa MD, Murat Şakir Ekşi MD |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Central Nervous System Disease, Vol 15 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1179-5735 11795735 |
| DOI: | 10.1177/11795735231195760 |
| Popis: | Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin’s action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis. |
| Databáze: | Directory of Open Access Journals |
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