| Autor: |
Junko Tanuma, Awachana Jiamsakul, Abhimanyu Makane, Anchalee Avihingsanon, Oon Tek Ng, Sasisopin Kiertiburanakul, Romanee Chaiwarith, Nagalingeswaran Kumarasamy, Kinh Van Nguyen, Thuy Thanh Pham, Man Po Lee, Rossana Ditangco, Tuti Parwati Merati, Jun Yong Choi, Wing Wai Wong, Adeeba Kamarulzaman, Evy Yunihastuti, Benedict Lh Sim, Winai Ratanasuwan, Pacharee Kantipong, Fujie Zhang, Mahiran Mustafa, Vonthanak Saphonn, Sanjay Pujari, Annette H Sohn, TREAT Asia HIV Observational Databases (TAHOD) |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 11, Iss 8, p e0161562 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0161562 |
| Popis: |
BACKGROUND:In resource-limited settings, routine monitoring of renal function during antiretroviral therapy (ART) has not been recommended. However, concerns for tenofovir disoproxil fumarate (TDF)-related nephrotoxicity persist with increased use. METHODS:We investigated serum creatinine (S-Cr) monitoring rates before and during ART and the incidence and prevalence of renal dysfunction after starting TDF by using data from a regional cohort of HIV-infected individuals in the Asia-Pacific. Time to renal dysfunction was defined as time from TDF initiation to the decline in estimated glomerular filtration rate (eGFR) to 30% reduction from baseline using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation or the decision to stop TDF for reported TDF-nephrotoxicity. Predictors of S-Cr monitoring rates were assessed by Poisson regression and risk factors for developing renal dysfunction were assessed by Cox regression. RESULTS:Among 2,425 patients who received TDF, S-Cr monitoring rates increased from 1.01 to 1.84 per person per year after starting TDF (incidence rate ratio 1.68, 95%CI 1.62-1.74, p 50 vs. ≤30, hazard ratio [HR] 5.39, 95%CI 2.52-11.50, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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