Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity

Autor: Xiangqi Fan, Haiyan Hu, Daiwen Chen, Bing Yu, Jun He, Jie Yu, Junqiu Luo, Erik Eckhardt, Yuheng Luo, Jianping Wang, Hui Yan, Xiangbing Mao
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Animal Science and Biotechnology, Vol 12, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2049-1891
DOI: 10.1186/s40104-021-00562-6
Popis: Abstract Background Lentinan (LNT) may regulate many important physiological functions of human and animals. This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs. Methods Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d (n = 14). RV infection was executed on d 15. After extracting polysaccharides from LNT product, its major monosaccharides were analyzed. Then, LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells. Results Dietary LNT supplementation supported normal function of piglets even when infected with RV, as reflected by reduced growth performance loss and diarrhea prevalence, and maintained gut immunity (P
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