Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment

Autor:	Jon G. Steller, Jeffrey R. Alberts, April E. Ronca
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	oxidative stress cosmic radiation microgravity hind-limb unloading spaceflight reproduction female pregnancy Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 19, Iss 12, p 3729 (2018)
Druh dokumentu:	article
ISSN:	1422-0067
DOI:	10.3390/ijms19123729
Popis:	Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes.
Databáze:	Directory of Open Access Journals
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