Adult onset lung disease following transient disruption of fetal stretch-induced differentiation

Autor: Cohen J Craig, Chandran Ashok, Killeen Erin, Hudak Joseph J, Larson Janet E
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Respiratory Research, Vol 10, Iss 1, p 34 (2009)
Druh dokumentu: article
ISSN: 1465-9921
02367467
DOI: 10.1186/1465-9921-10-34
Popis: Abstract One of the mechanisms by which adult disease can arise from a fetal origin is by in utero disruption of organogenesis. These studies were designed to examine respiratory function changes in aging rats following transient disruption of lung growth at 16 days gestation. Fetuses were treated in utero with a replication deficient adenovirus containing the cystic fibrosis conductance transmembrane regulator (CFTR) gene fragment cloned in the anti-sense direction. The in utero-treated rats demonstrated abnormal lung function beginning as early as 30 days of age and the pathology progressed as the animals aged. The pulmonary function abnormalities included decreased static compliance as well as increased conducting airway resistance, tissue damping, and elastance. Pressure volume (PV) curves demonstrated a slower early rise to volume and air trapping at end-expiration. The alterations of pulmonary function correlated with lung structural changes determined by morphometric analysis. These studies demonstrate how transient disruption of lung organogensis by single gene interference can result in progressive change in lung function and structure. They illustrate how an adult onset disease can arise from subtle changes in gene expression during fetal development.
Databáze: Directory of Open Access Journals
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