Effects of Treadmill Exercise on Autistic Behavior and Prefrontal Cortical SHANK Receptors in Autism Spectrum Disorder Model Mice

Autor:	Kyeong-Ri Kim, Tae-Kyung Kim, Joon-Yong Cho
Jazyk:	korejština
Rok vydání:	2024
Předmět:	shank3b knock-out (ko) repetitive behavior social interaction glutamate receptor Nutrition. Foods and food supply TX341-641 Biochemistry QD415-436
Zdroj:	운동과학, Vol 33, Iss 1, Pp 46-55 (2024)
Druh dokumentu:	article
ISSN:	1226-1726 2384-0544
DOI:	10.15857/ksep.2024.00087
Popis:	PURPOSE The first aim of this study is to change autistic behavior in Shank3B Knock-Out (KO) mice through treadmill exercise (TD), and the second aim is to alter SHANK protein receptors in the prefrontal cortex (PFC) of mice through TD. METHODS Male mice were divided into Control (11-week-old, n=8), Control+TD (n=8), Shank3B KO (n=8), and Shank3B KO+TD (n=8). Control and Shank3B KO mice were exercised using TD for 2 weeks for 30 minutes each to observe the effects of exercise. RESULTS Compared to the control group (C57BL/6J), Shank3B KO mice showed excessive self-grooming behavior; however, TD reduced repetitive behavior (p
Databáze:	Directory of Open Access Journals
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