An experimental study on phytochemical composition and memory enhancing effect of Ginkgo biloba seed extract

Autor: Teodora Tomova, Nina Doncheva, Anita Mihaylova, Ilia Kostadinov, Lyudmil Peychev, Mariana Argirova
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Folia Medica, Vol 63, Iss 2, Pp 203-212 (2021)
Druh dokumentu: article
ISSN: 1314-2143
DOI: 10.3897/folmed.63.e53060
Popis: Introduction: The Ginkgo biloba L. tree is considered as one of the oldest species on Earth. It is known as a “living fossil” dating back approximately 200 million years. Both the leaves and seeds of this tree have been used for millennia in traditional Chinese medicine.Aim: To study the phytochemical profile of Gingko biloba seed extract (GBSE) and its memory enhancing effects.Materials and methods: Liquid chromatography with mass detection (LC-MS) was performed for phytochemical analyses of the extracts. For the in vivo experiments, male Wistar rats were divided randomly into 5 groups (n=8): saline; piracetam; GBSE 50; 100, and 200 mg/kg b.w. Y-maze, T-maze, step-down passive avoidance and novel object recognition test (NORT) were performed. The observed parameters were: percentage of spontaneous alternations (% SA), working memory index, latency of reaction and recognition index, respectively. Statistical analysis was done using SPSS 19.Results: LC-MS analysis showed the presence of the flavonoids quercetin, kaempferol and isorhamnetin (as aglycones), the ginkgolides A, B, C, J, and bilobalide. In Y-maze task, the groups treated with 50 and 100 mg/kg of GBSE significantly increased the % SA during the memory test compared to saline (p
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