Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1
| Autor: | P. Šmerák, I. Bárta, Z. Polívková, J. Bártová, M. Sedmíková |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Czech Journal of Food Sciences, Vol 19, Iss 3, Pp 90-96 (2001) |
| Druh dokumentu: | article |
| ISSN: | 1212-1800 1805-9317 |
| DOI: | 10.17221/6583-CJFS |
| Popis: | The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1,which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD50). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB1 alone in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1). |
| Databáze: | Directory of Open Access Journals |
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