Curative potential of Gbogbonise Epa Ijebu herbal remedy in male Wistar rats infected with Salmonella enterica serovar typhi
| Autor: | Seyi Samson Enitan, Michael Olugbamila Dada, Oluwafemi Omoniyi Oguntibeju, Emmanuel Olusegun Ileoma, Saratu Omagbemi Ajike, Victor Ayodele Aderogba |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Herbal Drugs, Vol 13, Iss 3, Pp 25-38 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2008-8884 2476-5392 |
| DOI: | 10.30495/MEDHERB.2022.698253 |
| Popis: | Background & Aim: Commercially sold herbal remedies are fast gaining recognition among the Nigerian populace for the treatment of various ailments. The aim of this study was to assess the curative potential of Gbogbonise Epa Ijebu herbal remedy in male Wistar rats infected with Salmonella enteric serovar typhi (S.typhi). Experimental: A total of 60 male Wistar rats weighing 150+50 g (mean+SD) were randomly assigned into 10 groups of 6 rats each. Group 1, 2, 3, 7, 8, 9 and 10 were infected with one ml of S. typhi suspension with a concentration of 106 CFU/mL in phosphate buffered saline (PBS). Group 4, 5 and 6 which served as the Zero control, undiluted herbal control and diluted herbal control, respectively. Group 7 and were 8 were treated with 500 mg/Kg/bid and 250 mg/kg/bid herbal remedy, respectively, while group 9 and 10 were treated with equal volume of Ciprofloxacin and herbal remedy, 500 mg/kg/bid and 250 mg/kg/bid, respectively, orally twice daily for 7days. Bacterial loads in rectal swab, intestine and gall bladder, as well as the anti-S.typhi O and H serum antibodies of the test and control rats were evaluated at pre-infection, post-infection and post-treatment phases using standard microbiological and serological methods. Results: The outcome of this study showed that the administration of the herbal remedy (500 mg/Kg/bid) resulted in a significant reduction (P |
| Databáze: | Directory of Open Access Journals |
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