Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review
Autor: | Rafael Silva Santos, Kahynna Cavalcante Loureiro, Polyana Santos Rezende, Luciana Nalone Andrade, Raquel de Melo Barbosa, Antonello Santini, Ana Cláudia Santos, Classius Ferreira da Silva, Eliana Barbosa Souto, Damião Pergentino de Sousa, Ricardo Guimarães Amaral, Patrícia Severino |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Journal of Dermatological Treatment, Vol 30, Iss 6, Pp 617-626 (2019) |
Druh dokumentu: | article |
ISSN: | 0954-6634 1471-1753 09546634 71462899 |
DOI: | 10.1080/09546634.2018.1479726 |
Popis: | Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect. The topical route is desirable due to the adverse effects arising from oral administration. This review provides a comprehensive analysis of the use of nano compounds for the current treatment of topical fungal infections. A special emphasis is given to the employment of lipid nanoparticles, due to their recognized efficacy, versatility, and biocompatibility, attracting the major attention as novel topical nanocompounds used for the administration of antifungal drugs. |
Databáze: | Directory of Open Access Journals |
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