| Autor: |
Carlos Henrique F. Peiró, Matheus M. Perez, Glauco S. A. de Aquino, Jéssica F. A. Encinas, Luiz Vinícius de A. Sousa, Glaucia Luciano da Veiga, Auro del Giglio, Fernando L. A. Fonseca, Beatriz da Costa Aguiar Alves |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-87897-2 |
| Popis: |
Abstract In tumor cells, higher expression of glucose transporter proteins (GLUT) and carbonic anhydrases (CAIX) genes is influenced by hypoxia-induced factors (HIF).Thus, we aimed to study the expression profile of these markers in sequential peripheral blood collections performed in breast cancer patients in order to verify their predictive potential in liquid biopsies. Gene expressions were analyzed by qPCR in tumor and blood samples from 125 patients and 25 healthy women. Differential expression was determined by the 2(−ΔCq) method. Expression of HIF-1α and GLUT1 in the blood of breast cancer patients is significantly higher (90–91 and 160–161 fold increased expression, respectively; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
