| Autor: |
Joseph R. Starnes, Meng Xu, Kristen George‐Durrett, Kimberly Crum, Frank J. Raucci, Christopher F. Spurney, Kan N. Hor, Linda H. Cripe, Nazia Husain, Sujatha Buddhe, Katheryn Gambetta, Jaclyn Tamaroff, James C. Slaughter, Larry W. Markham, Jonathan H. Soslow |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.123.032960 |
| Popis: |
Background Cardiovascular disease is the leading cause of death among patients with Duchenne muscular dystrophy (DMD). Identifying patients at risk of early death could allow for increased monitoring and more intensive therapy. Measures that associate with death could serve as surrogate outcomes in clinical trials. Methods and Results Duchenne muscular dystrophy subjects prospectively enrolled in observational studies were included. Models using generalized least squares were used to assess the difference of cardiac magnetic resonance measurements between deceased and alive subjects. A total of 63 participants underwent multiple cardiac magnetic resonance imaging and were included in the analyses. Twelve subjects (19.1%) died over a median follow‐up of 5 years (interquartile range, 3.1–7.0). Rate of decline in left ventricular ejection fraction was faster in deceased than alive subjects (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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