TRPA1s act as chemosensors but not as cold sensors or mechanosensors to trigger the swallowing reflex in rats

Autor:	Mohammad Zakir Hossain, Hiroshi Ando, Shumpei Unno, Junichi Kitagawa
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 12, Iss 1, Pp 1-21 (2022)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-022-07400-3
Popis:	Abstract We examined the role of TRPA1s in triggering the swallowing reflex. TRPA1s predominantly localized on thin nerve fibers and fibroblast-like cells in swallowing-related regions and on small to medium-sized superior laryngeal nerve-afferents in the nodose–petrosal–jugular ganglionic complex. Topical application of a TRPA1 agonist, allyl isothiocyanate (AITC), dose-dependently triggered swallowing reflexes. Prior topical application of a TRPA1 antagonist significantly attenuated the AITC-induced reflexes. Application of cold AITC (4 °C) very briefly reduced the on-site temperature to
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9ff23ee790684e6087fa8de33e8fb494 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.