INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS
| Autor: | Денис Сергеевич Загрешенко, Андрей Владимирович Климов, Владимир Васильевич Климов, Наталья Сергеевна Кошкарова, Оксана Анатольевна Найдина, Екатерина Юрьевна Цыплина |
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| Jazyk: | ruština |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Medicina v Kuzbasse, Vol 22, Iss 3, Pp 21-26 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1819-0901 2588-0411 |
| Popis: | The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any inflammatory process, including allergic inflammation. The review article describes a structure, major activation signals, NLRP1 activation process, and assotiation with human disease, focusing on atopic conditions, such as atopic dermatitis, allergic rhinitis, and allergic asthma, and provides a rationale for the link of mutations in the NLRP1 sensor gene with genes corresponding to atopy predisposition. The association of NLRP1 with malignant neoplasms is also reported. |
| Databáze: | Directory of Open Access Journals |
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