Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Autor:	Bindu D. Paul, Andrew A. Pieper
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	bilirubin biliverdin reductase superoxide lipophilic antioxidant cognition Microbiology QR1-502
Zdroj:	Biomolecules, Vol 14, Iss 2, p 155 (2024)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom14020155
Popis:	Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.
Databáze:	Directory of Open Access Journals
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