| Autor: |
Atanaska Marinova-Petkova, Mohammed M Feeroz, SM Rabiul Alam, M Kamrul Hasan, Sharmin Akhtar, Lisa Jones-Engel, David Walker, Laura McClenaghan, Adam Rubrum, John Franks, Patrick Seiler, Trushar Jeevan, Pamela McKenzie, Scott Krauss, Richard J Webby, Robert G Webster |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Emerging Microbes and Infections, Vol 3, Iss 1, Pp 1-14 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2222-1751 |
| DOI: |
10.1038/emi.2014.11 |
| Popis: |
Highly pathogenic H5N1 and low pathogenic H9N2 influenza viruses are endemic to poultry markets in Bangladesh and have cocirculated since 2008. H9N2 influenza viruses circulated constantly in the poultry markets, whereas highly pathogenic H5N1 viruses occurred sporadically, with peaks of activity in cooler months. Thirty highly pathogenic H5N1 influenza viruses isolated from poultry were characterized by antigenic, molecular, and phylogenetic analyses. Highly pathogenic H5N1 influenza viruses from clades 2.2.2 and 2.3.2.1 were isolated from live bird markets only. Phylogenetic analysis of the 30 H5N1 isolates revealed multiple introductions of H5N1 influenza viruses in Bangladesh. There was no reassortment between the local H9N2 influenza viruses and H5N1 genotype, despite their prolonged cocirculation. However, we detected two reassortant H5N1 viruses, carrying the M gene from the Chinese H9N2 lineage, which briefly circulated in the Bangladesh poultry markets and then disappeared. On the other hand, interclade reassortment occurred within H5N1 lineages and played a role in the genesis of the currently dominant H5N1 viruses in Bangladesh. Few ‘human-like’ mutations in H5N1 may account for the limited number of human cases. Antigenically, clade 2.3.2.1 H5N1 viruses in Bangladesh have evolved since their introduction and are currently mainly homogenous, and show evidence of recent antigenic drift. Although reassortants containing H9N2 genes were detected in live poultry markets in Bangladesh, these reassortants failed to supplant the dominant H5N1 lineage. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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