Host-associated Genetic Import in Campylobacter jejuni
| Autor: | Noel D. McCarthy, Frances M. Colles, Kate E. Dingle, Mary C. Bagnall, Georgina Manning, Martin C.J. Maiden, Daniel Falush |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 13, Iss 2, Pp 267-272 (2007) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid1302.060620 |
| Popis: | Establishing sources of human infection supports effective disease control measures. Host association with Campylobacter jejuni was analyzed by using multilocus sequence typing data for 713 isolates from chickens and bovids (cattle and sheep). Commonly used summary measures of genotypes (sequence type and clonal complex) showed poor accuracy, but a method using the full allelic profile showed 80% accuracy in distinguishing isolates from these 2 host groups. We explored the biologic basis of more accurate results with allelic profiles. Strains isolated from specific hosts have imported a substantial number of alleles while circulating in those host species. These results imply that 1) although Campylobacter moves frequently between hosts, most transmission is within species, and 2) lineages can acquire a host signature and potentially adapt to the host through recombination. Assignment using this signature enables improved prediction of source for pathogens that undergo frequent genetic recombination. |
| Databáze: | Directory of Open Access Journals |
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