Predictors of change in early child development among children with stunting: Secondary analysis of a randomized trial in Uganda.

Autor: Joseph Mbabazi, Hannah Pesu, Rolland Mutumba, Gareth McCray, Christian Ritz, Suzanne Filteau, André Briend, Ezekiel Mupere, Benedikte Grenov, Henrik Friis, Mette F Olsen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PLOS Global Public Health, Vol 4, Iss 8, p e0003456 (2024)
Druh dokumentu: article
ISSN: 2767-3375
DOI: 10.1371/journal.pgph.0003456
Popis: Millions of children under 5 years in low- and middle-income countries fail to attain their development potential with accruing short- and long-term consequences. Low length/height for age (stunting) is known to be a key factor, but there is little data on how child characteristics are linked with developmental changes among children with stunting. We assessed the socioeconomic, household, anthropometric, and clinical predictors of change in early child development (ECD) among 1-5-year-old children with stunting. This was a prospective cohort study nested in a randomized trial testing effects of lipid-based nutrient supplementation among children with stunting in Uganda. Development was assessed using the Malawi Development Assessment Tool (MDAT). Multiple linear regression analysis was used to assess for predictors of change. We included 750 children with mean ±SD age of 30.2 ±11.7 months 45% of whom were female. After 12 weeks, total MDAT z-score increased by 0.40 (95%CI: 0.32; 0.48). Moderate vs severe stunting, higher fat-free mass, negative malaria test and no inflammation (serum α-1-acid glycoprotein
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