Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival

Autor: Dong-il Kwon, Eun Seo Park, Mingyu Kim, Yoon Ha Choi, Myeong-seok Lee, Si-hyung Joo, Yeon-Woo Kang, Minji Lee, Saet-byeol Jo, Seung-Woo Lee, Jong Kyoung Kim, You Jeong Lee
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29032-x
Popis: Elevated levels of IgE is associated with a range of allergic pathology but the source of such IgE producing B cells during the steady state is poorly understood. Here, Kwon et al. show that homeostatic IgE is secreted by plasma cells in the thymus and link this to mast cell survival.
Databáze: Directory of Open Access Journals