| Autor: |
Emanuela S. Fioretta, PhD, Valentina Lintas, PhD, Anna Mallone, PhD, Sarah E. Motta, PhD, Lisa von Boehmer, DVM, Petra E. Dijkman, PhD, Nikola Cesarovic, DVM, PhD, Etem Caliskan, MD, Héctor Rodriguez Cetina Biefer, MD, Miriam Lipiski, DVM, Mareike Sauer, DVM, Matilde Putti, PhD, Henk M. Janssen, PhD, Serge H. Söntjens, PhD, Anthal I.P.M. Smits, PhD, Carlijn V.C. Bouten, PhD, Maximilian Y. Emmert, MD, PhD, Simon P. Hoerstrup, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 15-31 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2452-302X |
| DOI: |
10.1016/j.jacbts.2019.09.008 |
| Popis: |
Summary: This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach. Key Words: cardiovascular regenerative medicine, endogenous tissue regeneration, in situ tissue engineering, supramolecular polymer, tissue-engineered heart valve |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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