Fas versatile signaling and beyond: Pivotal role of tyrosine phosphorylation in context-dependent signaling and diseases.

Autor: Krittalak Chakrabandhu, Anne-Odile HUEBER
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Frontiers in Immunology, Vol 7 (2016)
Druh dokumentu: article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2016.00429
Popis: The Fas/FasL system is known, first and foremost, as a potent apoptosis activator. While its pro-apoptotic features have been studied extensively, evidence that the Fas/FasL system can elicit non-death signals has also accumulated. These non-death signals can promote survival, proliferation, migration, as well as invasion of cells. The key molecular mechanism that determines the shift from cell death to non-death signals had remained unclear until the recent identification of the tyrosine phosphorylation in the death domain of Fas as the reversible signaling switch. In this review, we present the connection between the recent findings regarding the control of Fas multi-signals and the context-dependent signaling choices. This information can help explain variable roles of Fas signaling pathway in different pathologies.
Databáze: Directory of Open Access Journals