Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy

Autor: Anna Witasp, Karin Luttropp, Abdul Rashid Qureshi, Peter Barany, Olof Heimbürger, Lars Wennberg, Tomas J. Ekström, Paul G. Shiels, Peter Stenvinkel, Louise Nordfors
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-04321-5
Popis: Abstract Chronic kidney disease (CKD) is an emerging public health priority associated with high mortality rates and demanding treatment regimens, including life-style changes, medications or even dialysis or renal transplantation. Unavoidably, the uremic milieu disturbs homeostatic processes such as DNA methylation and other vital gene regulatory mechanisms. Here, we aimed to investigate how dialysis or kidney transplantation modifies the epigenome-wide methylation signature over 12 months of treatment. We used the Infinium HumanMethylation450 BeadChip on whole blood samples from CKD-patients undergoing either dialysis (n = 11) or kidney transplantation (n = 12) and 24 age- and sex-matched population-based controls. At baseline, comparison between patients and controls identified several significant (PFDR
Databáze: Directory of Open Access Journals
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