Novel low-grade inflammation markers in children with attention deficit hyperactivity disorder

Autor: Duygu Kaba
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Gülhane Tıp Dergisi, Vol 66, Iss 2, Pp 68-73 (2024)
Druh dokumentu: article
ISSN: 2146-8052
DOI: 10.4274/gulhane.galenos.2023.33602
Popis: Aims: The course of low-grade inflammation markers, including platelet-monocyte ratio (PMR), mean platelet volume-lymphocyte ratio (MPVLR), and the mean platelet volume-platelet ratio (MPVPR), is not known in children with Attention Deficit Hyperactivity Disorder (ADHD). The primary objective of this study was to compare PMR, MPVLR, and MPVPR in children with ADHD versus healthy controls. Methods: A retrospective, case-control, cross-sectional study was performed with children aged 6-18 years with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. An age, gender, and body mass index-matched healthy control group was formed. Platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), basophil-lymphocyte ratio (BLR), PMR, MPVLR, MPVPR, and systemic immunity-inflammation index (SII) were compared between the two groups. Results: The study included 79 children with ADHD and 70 controls. NLR, BLR, SII, PMR, and MPVPR were not significantly different between the two groups. However, the PLR was higher in the ADHD group than in the control group (p
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