| Autor: |
Manuel Veas Porlán, Antonio Tello-Montoliu, Cecilia López-García, Pablo Gil-Pérez, Miriam Quintana-Giner, Raquel López-Gálvez, José Miguel Rivera-Caravaca, Francisco Marín, Domingo Pascual Figal |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
International Journal of Cardiology: Heart & Vasculature, Vol 46, Iss , Pp 101195- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2352-9067 |
| DOI: |
10.1016/j.ijcha.2023.101195 |
| Popis: |
Background: Chronic renal failure (CKD) is associated with the presence of increased platelet reactivity and lower clinical benefit of clopidogrel. Ticagrelor has a more favorable pharmacodynamic and pharmacokinetic profile compared to clopidogrel, which has translated into better clinical outcomes in patients with acute coronary syndrome (ACS). We conducted a prospective mechanistic cohort study in order to investigate the impact of renal failure on the pharmacokinetics and pharmacodynamics of ticagrelor in patients with acute ACS. Methods: Patients were divided into two groups based on their estimated renal clearances (eGFR ≥ 60 mL/min and eGFR |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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