Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity

Autor: Cezar M. Tigaret, Valeria Olivo, Josef H.L.P. Sadowski, Michael C. Ashby, Jack R. Mellor
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms10289
Popis: During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated activation of NMDARs and VGCCs and their regulation by mGluRs and SK channels.
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