| Autor: |
Sojung Won, Jane Melissa Lim, Jin Hwan Lee, Young J. Oh, Jin-Hee Shin, Byoung Joo Gwag, Eui-Ju Choi |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Cosmetics, Vol 11, Iss 5, p 158 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2079-9284 |
| DOI: |
10.3390/cosmetics11050158 |
| Popis: |
Oxidative stress is a primary contributor to human skin aging, while antioxidants are known to mitigate skin damage related to aging processes. In this study, we investigated the possible action of trifluoromethyl phenethyl mesalazine (TFM), an antioxidizing agent, on skin aging processes, including skin wrinkles and pigmentation. Our data revealed that TFM exerted a strong free radical scavenging capability and notably inhibited melanin production. Moreover, TFM downregulated the UV-induced production of matrix metalloproteinase-1 and interleukin-6 in cultured human skin fibroblasts. Furthermore, in a clinical study with 24 women, TFM significantly reduced skin wrinkles and improved skin brightness compared to a placebo. These findings highlight the previously unrecognized effects of TFM on skin health by mitigating skin aging processes associated with oxidative damage. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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