The efficacy of platelet rich plasma on anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Autor:	Zheng-Tao Lv, Jin-Ming Zhang, Zhi-Ying Pang, Zhe Wang, Jun-Ming Huang, Wen-Tao Zhu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	anterior cruciate ligament reconstruction biologic healing enhancement meta-analysis pain platelet-rich plasma systematic review Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Platelets, Vol 33, Iss 2, Pp 229-241 (2022)
Druh dokumentu:	article
ISSN:	0953-7104 1369-1635 09537104
DOI:	10.1080/09537104.2021.1902969
Popis:	Anterior cruciate ligament (ACL) rupture is a common musculoskeletal injury, most frequently affecting young and physically active patients. Platelet-rich plasma (PRP) has been widely used in ACL reconstruction to augment the graft healing. However, high-level studies addressing its clinical efficacy could not reach a consensus. In this study, we assess the efficacy of PRP on pain relief, functional improvement along with radiological changes in patients who underwent ACL reconstruction. We performed comprehensive literature search and included 17 RCTs containing 970 participants who underwent ACL reconstruction. The combined data showed significant difference between PRP and control with regard to VAS score (MD: −1.12, 95% CI −1.92, −0.31; P = .007), subjective IKDC score (MD: 6.08, 95% CI 4.39, 7.77; P
Databáze:	Directory of Open Access Journals
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