Correction of heat-induced susceptibility changes in respiratory-triggered 2D-PRF-based thermometry for monitoring of magnetic resonance-guided hepatic microwave ablation in a human-like in vivo porcine model
| Autor: | Bennet Hensen, Susanne Hellms, Christopher Werlein, Danny Jonigk, Phillip Alexander Gronski, Inga Bruesch, Regina Rumpel, Eva-Maria Wittauer, Florian W. R. Vondran, Dennis L. Parker, Frank Wacker, Marcel Gutberlet |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal of Hyperthermia, Vol 39, Iss 1, Pp 1387-1396 (2022) |
| Druh dokumentu: | article |
| ISSN: | 02656736 1464-5157 0265-6736 |
| DOI: | 10.1080/02656736.2022.2138987 |
| Popis: | Purpose To develop and evaluate susceptibility corrected 2D proton resonance frequency (PRF)-based magnetic resonance (MR)-thermometry for the accurate assessment of the ablation zone of hepatic microwave ablation (MWA).Methods and materials Twelve hepatic MWA were performed in five LEWE minipigs with human-like fissure-free liver. Temperature maps during ablation of PRF-based MR-thermometry were corrected by modeling heat induced susceptibility changes. Ablation zones were determined using cumulative equivalent minutes at 43 °C (CEM43) as tissue damage model. T1 weighted (w) post-ablation contrast-enhanced (CE) MR-imaging and manually segmented postmortem histology were used for validation. The agreement of uncorrected (raw) and susceptibility corrected (corr) MR-thermometry with T1w post-ablation CE MR-imaging and histology was evaluated. The Wilcoxon-signed rank test and Bland–Altman analysis were applied.Results With the susceptibility corrected MR-thermometry a significantly increased dice coefficient (raw: 77% vs. corr: 83%, p |
| Databáze: | Directory of Open Access Journals |
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