| Autor: |
Inten Pangestika, Efriyana Oksal, Tengku Sifzizul Tengku Muhammad, Hermansyah Amir, Desy Fitrya Syamsumir, Mohd Effendy Abdul Wahid, Yosie Andriani |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 1947-1960 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1319-562X |
| DOI: |
10.1016/j.sjbs.2020.06.010 |
| Popis: |
One of the pathways to reduce cholesterol production in the liver is through the inhibition of HMG-Coa reductase (HMGCR) by current drugs, statins. However, these have side effects if consumed in prolonged periods. Tangeretin and trans-ethyl caffeate as alternative drugs in reducing hypercholesterolemia and preventing atherosclerosis have never been reported. Their effects on inhibiting HMGCR activity were investigated through enzymatic method (in vitro and in vivo). The toxicity property was analyzed on the Serum Glutamate Oxalate Transaminase (SGOT)/Serum Glutamate Piruvate Transaminase (SGPT) levels and rat liver histology. The results showed that both compounds inhibited HMGCR activity significantly compare to the control simvastatin (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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