Animal models of pulmonary arterial hypertension associated with atrial septal defect

Autor:	Li Wang, Ting Tang, Xiaochun Tian, Chang Peng, Shuqi Wu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Animal model Pulmonary arterial hypertension Atrial septostomy Rat Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-69002-5
Popis:	Abstract Pulmonary arterial hypertension (PAH) is a well-known complication of congenital heart disease (CHD). The lack of a satisfactory animal model for PAH associated with CHD (PAH-CHD) has limited progress in understanding the pathogenesis of PAH and the development of therapeutic agents. The development of a rat model for PAH associated with atrial septal defect (ASD) was achieved through atrial septal puncture and thermal ablation. Two and 4 weeks after modeling, hematoxylin and eosin staining showed that the vascular thickness, vascular thickness index, vascular area, and vascular area index in pulmonary arteries with an outer diameter of 50–300 μm in the PAH-ASD 2 and 4 weeks group were higher than those in the sham group (all P
Databáze:	Directory of Open Access Journals
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