Anticancer Effects of Five Biflavonoids from Ginkgo Biloba L. Male Flowers In Vitro

Autor: Min Li, Bin Li, Zi-Ming Xia, Ying Tian, Dan Zhang, Wen-Jing Rui, Jun-Xing Dong, Feng-Jun Xiao
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecules, Vol 24, Iss 8, p 1496 (2019)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules24081496
Popis: Ginkgo biloba L., an ancient dioecious gymnosperm, is now cultivated worldwide for landscaping and medical purposes. A novel biflavonoid—amentoflavone 7′′-O-β-d-glucopyranoside (1)—and four known biflavonoids were isolated and identified from the male flowers of Ginkgo. The anti-proliferative activities of five biflavonoids were evaluated on different cancer lines. Bilobetin (3) and isoginkgetin (4) exhibited better anti-proliferative activities on different cancer lines. Their effects were found to be cell-specific and in a dose and time dependent manner for the most sensitive HeLa cells. The significant morphological changes validated their anticancer effects in a dose-dependent manner. They were capable of arresting the G2/M phase of the cell cycle, inducing the apoptosis of HeLa cells dose-dependently and activating the proapoptotic protein Bax and the executor caspase-3. Bilobetin (3) could also inhibit the antiapoptotic protein Bcl-2. These might be the mechanism underlying their anti-proliferation. In short, bilobetin (3) and isoginkgetin (4) might be the early lead compounds for new anticancer agents.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje