Developmental Dyslexia: Insights from EEG-Based Findings and Molecular Signatures—A Pilot Study

Autor: Daniela Theodoridou, Christos-Orestis Tsiantis, Angeliki-Maria Vlaikou, Vasiliki Chondrou, Victoria Zakopoulou, Pavlos Christodoulides, Emmanouil D. Oikonomou, Katerina D. Tzimourta, Charilaos Kostoulas, Alexandros T. Tzallas, Konstantinos I. Tsamis, Dimitrios Peschos, Argyro Sgourou, Michaela D. Filiou, Maria Syrrou
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Brain Sciences, Vol 14, Iss 2, p 139 (2024)
Druh dokumentu: article
ISSN: 2076-3425
DOI: 10.3390/brainsci14020139
Popis: Developmental dyslexia (DD) is a learning disorder. Although risk genes have been identified, environmental factors, and particularly stress arising from constant difficulties, have been associated with the occurrence of DD by affecting brain plasticity and function, especially during critical neurodevelopmental stages. In this work, electroencephalogram (EEG) findings were coupled with the genetic and epigenetic molecular signatures of individuals with DD and matched controls. Specifically, we investigated the genetic and epigenetic correlates of key stress-associated genes (NR3C1, NR3C2, FKBP5, GILZ, SLC6A4) with psychological characteristics (depression, anxiety, and stress) often included in DD diagnostic criteria, as well as with brain EEG findings. We paired the observed brain rhythms with the expression levels of stress-related genes, investigated the epigenetic profile of the stress regulator glucocorticoid receptor (GR) and correlated such indices with demographic findings. This study presents a new interdisciplinary approach and findings that support the idea that stress, attributed to the demands of the school environment, may act as a contributing factor in the occurrence of the DD phenotype.
Databáze: Directory of Open Access Journals
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