Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer

Autor: Xiangbin Xing, Weibin Cai, Sanmei Ma, Yongfei Wang, Huijuan Shi, Ming Li, Jinxia Jiao, Yang Yang, Longshan Liu, Xiangliang Zhang, Minhu Chen
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Druh dokumentu: article
ISSN: 1471-2407
DOI: 10.1186/s12885-017-3203-y
Popis: Abstract Background OPCML belongs to the IgLON family of Ig domain–containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear. Methods We assessed expression and biological behavior of OPCML in gastric cancer. Results OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0.007) and grading (p
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