TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia

Autor:	Yan Qian, Xiao Li, Xinyu Li, Xijie Zhang, Qi Yuan, Zhengxia Wang, Mingshun Zhang, Mao Huang, Ningfei Ji
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Organizing pneumonia TOM5 alveolar epithelial cells mitochondrial membrane potential bleomycin Pathology RB1-214 Biology (General) QH301-705.5
Zdroj:	Redox Report, Vol 29, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	13510002 1743-2928 1351-0002
DOI:	10.1080/13510002.2024.2354625
Popis:	Deficiency of TOM5, a mitochondrial protein, causes organizing pneumonia (OP) in mice. The clinical significance and mechanisms of TOM5 in the pathogenesis of OP remain elusive. We demonstrated that TOM5 was significantly increased in the lung tissues of OP patients, which was positively correlated with the collagen deposition. In a bleomycin-induced murine model of chronic OP, increased TOM5 was in line with lung fibrosis. In vitro, TOM5 regulated the mitochondrial membrane potential in alveolar epithelial cells. TOM5 reduced the proportion of early apoptotic cells and promoted cell proliferation. Our study shed light on the roles of TOM5 in OP.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9f5a6e182b5d495eab3d81d7e3b4c3cb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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