Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study

Autor:	Ran Zhao, WeiLi Wang, Wen Zhang, JiaPeng Lu, Yi Liu, Jing Guo, Lu Yang, ZeDan Zhang, Chang He, XinYi Gu, Bin Wang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Statins Diabetic nephropathy Diabetic retinopathy Mendelian randomization HMGCR Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-67800-5
Popis:	Abstract There is no reliable causal evidence for the effect of statins on diabetic nephropathy (DN) and diabetic retinopathy (DR), and the results of previous observational studies are contradictory. Genetic variants linked to low-density lipoprotein cholesterol (LDL-C) from a UK biobank genome-wide association study and located within a 100kb window around HMGCR were used to proxy statins, comparing with PCSK9 inhibitors (control). DN and DR genome-wide association study summary statistics were obtained from the FinnGen study. Secondary MR analyses and NHANES cross-sectional data were used for validation. Drug-target Mendelian randomization (MR) was applied to investigate the association between the genetically proxied inhibition of HMGCR and PCSK9 with DN and DR, p
Databáze:	Directory of Open Access Journals
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