| Autor: |
Anders P. Mutvei, Michal J. Nagiec, Jens C. Hamann, Sang Gyun Kim, C. Theresa Vincent, John Blenis |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-15156-5 |
| Popis: |
mTORC1 regulates cellular growth from the lysosome, but how changes in the organisation of the lysosomal system affect mTORC1 signalling is poorly understood. Here the authors show that amino acid-dependent Rap1-mediated changes in lysosomal abundance determine overall signalling output of mTORC1. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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