| Autor: |
Soon-Young Lee, Min-Hee Kim, Chun-Sik Bae, Hyuk Joon Choi, Eui Hyoun Ma, Sung-Jin Park, Seung-Sik Cho, Dae-Hun Park |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 107, Iss , Pp 105681- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2023.105681 |
| Popis: |
By 2030 the obese is prospected 20% of female and 14% of male and obesity induces many diseases. The active compounds in unripe C. unshiu peels were defined and anti-obesity effect was evaluated using with 3T3-L1 cell and high-fat diet mouse. In cell study the anti-obesity effect was analyzed using with oil red O stain and western blot and in animal study that was analyzed using with blood chemistry analysis, H&E stain, immunohistochemistry, RT-PCR, and ELISA. Thirty percentage ethanol extract of C. unshiu peels most effectively inhibited preadipocyte’s differentiation via PPARγ-C/EBPα pathway. In animal study it decreased the levels of LDL and leptin, suppressed fat accumulation, prevented adipogenesis via controlling PPARγ-C/EBPα-FAS, and inhibited inflammation via down-regulation of IL-1β, IL-13, and TNF-α. C. unshiu is a promising candidate for anti-obesity medication and for anti-inflammatory drug via regulating the level of leptin and the active compounds are supposed narirutin and hesperidin. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect